Lead Exposure Linked To Risk of Cardiovascular Disease

A 2026 publication in JAMA reports that long-term exposure to lead is strongly linked to a higher risk of dying from cardiovascular disease. Lead exposure is measured by how much accumulates in the body over time. Researchers analyzed data from more than 42,000 U.S. adults followed for decades and combined it with findings from prior studies worldwide. They found that as lead levels in the body increase, the risk of heart disease and stroke rises steadily, even at relatively low levels of exposure.

The study also estimated the global impact of lead exposure and found it remains a major public health problem. In 2023 alone, lead exposure was responsible for about 3.5 million deaths and over 70 million years of healthy life lost due to illness or early death. This represents nearly 6% of all deaths worldwide, making lead one of the leading environmental causes of cardiovascular disease.

Overall, the findings show that although lead exposure has decreased over time, its long-lasting effects continue to contribute significantly to preventable heart disease and death. The authors emphasize that stronger policies and efforts to reduce exposure could substantially improve global health.